Hey cyrus_b, I found that setting up the carputer on XP is pretty easy. Just depends on how far (or wild you imagination) is on what you want your carputer to do. If you have a system with WinXP installed, Centrafuse just installs like any app. Before I found Centrafuse I was expecting to have quite a bit of work on my hands to get it running with all the features I wanted. I'll update my install post on WinXP and Centrafuse in the next few days so you have something to reference if you want to install it. I did have a problem with bluetooth and also getting applications (such as Garmin My Mobile) to 'dock' with centrafuse (eg. the application opens inside centrafuse and not on top) but they were quickly overcome.
My suggestion; just download the Cenrafuse 30 day trial and install it on your home computer. I think you will be pleasantly surprised (as was I) when you see it running. You can use a mouse, in place of a touch screen, so you'll be able to try everything out. I'm more than happy to assist with Q's relating to setting up the software or hardware for one's own carputer; so feel free to post your experiences.

Eebuntu on the other hand is more of a challenge. eebuntu ran all drivers etc right out of the box so the install of the OS was a breeze. Where it becomes time consuming is getting all the little features working you might like to use. There's more 'customization' required to sort out things like emulation and more so, just finding software you can use, without resorting to writing BASH scripts and/or applications in higher level languages.
On your comment about audio: I must admit that I'm expecting some little audio niggles along the way; hum, buzz etc. We are dealing with an unbalanced audio system so it's most susceptible to noise along transmission lines and circuitry. That’s why they use a balanced configuration in professional / commercial grade systems. Switch mode PSU's are a big generator of noise as are fluro tubes. On the up side the new Lilliput screens are LED back lit (not cold cathode) and I will be using a regulated and filtered 12 DC PSU (no switchmode) for the EeePC. I'm most hopeful that I wont encounter any nasty noise but should I do, the remedies are generally inexpensive. That said noise can be a real pain to diagnose & fix sometimes, inexpensive but still a pain.
Once I get the LCD & EeePC installed I'll be able to see what effect they have on the car's audio. I'll be sure to post my experiences.
On a separate note, I must admit that im rather happy with the standard MAC - for an OEM (MY07 GT.B) system anyways. My preference is to set the base lower than mids or top end, so its louder without distortion. Almost all music is 'doctored' to the max these days so you'll always playing with the EQ.