I just read all 12 Pages of the H6 thread cynner linked to. Interesting read... Still a bit inconclusive though.
At the end of the day, it's all part of modifying. Even on bone stock cars, things will break eventually. With more power, some things will break sooner. I doubt anyone would say you will get the exact same lifespan out of an engine with increased performance, than you would stock.
I'd personally go the route of strengthen the engine before it breaks, coz I can choose when the downtime occurs. If it turns out that's what is needed, I'll accept that as part of running E85

. But deciding on what needs to be done to make the engine stand up to E85 (if anything at all) is another matter - still a bit of a newb in that regard.
And I'd still like to hear more guys with blown HGs on stock engines add their 2c, and who tuned them. It's not a blame game, it's just a risk we all take. Because Matt has a lot of guys running E85 without problems so far, so putting all E85 tunes (incl some that might've pushed the engine too far) in the same basket isn't fair.