That spec will poke, require guard rolling & clearancing, coilovers and potentially adjustable rear lateral arms.
18 8.5 +45 is master flush with coilovers, guard rolling and rear upper outer camber correction bushes.
Much of the considerations are ride height & tyre profile related, start with a cheap set of used tyres if you think that the sidewalls will get cut on your path to your perfect setup.
I’m on ps5 235 40 18 8.5 +35, coilovers, rear camber correction bushes, finger gap (horizontal tyre top to guard lower edge), stock alignment.
There’s around 5mm poke f&r which hasn’t been an issue apart from on gravel where rally mudflaps might help